Here’s what happened.
AstraZeneca manufactures Seroquel, the pharmaceutical trade name for quetiapine, a potent anti-psychotic that some believe mediate through antagonist activity at dopamine and serotonin receptors. Although the FDA had only approved Seroquel for schizophrenia and bipolar disorders, AstraZeneca had been marketing the drug to patients suffering from depression and anxiety, even though all disorders are not the same.
In 2001, Ted Baker, who lives in Bastrop, LA, was diagnosed with post-traumatic stress disorder, a depressive disorder. His doctor prescribed Seroquel. Baker, like many consumers of Seroquel, experienced “drastic weight gain” in a short time period. In 2004, Mr.Baker was diagnosed with Type II diabetes. However, Mr. Baker never knew and was never warned that the Seroquel had this dangerous side effect.
Now, after the fact, AstraZeneca wants the FDA to “expand” the use of Seroquel to include patients with depression and anxiety. Mr. Baker’s lawyers and many other lawyer believe that the “judicially sealed documents” surrounding Seroquel may well shed some light on the side effects of the drug. It seems that AstraZeneca “buried” unfavorable studies on the drug, according to an internal e-mail unsealed as part of litigation over the drug. The lawyers want all of the documents released to the FDA before the drug is officially approved for expanded use.
The problem, here, arises out of "judicial secrecy," which has been on the rise since the 1980s. It reached a climax in the 1990s. Without justification, indifferent conservative judges often willingly issue broad based "secrecy orders," protecting corporate predators and hiding evidence of inferior or bad pharmaceuticals from consumers.
To partially cure the problem, judicious secrecy needs to stop! To completely cure the problem, there needs to be corporate responsibility!
Here is the full release on the AstraZeneca case: Full release on the AstraZeneca case
Also, here are a few links to stories written on the case:
Associated Press: AstraZeneca challenges witnesses in Seroquel suit
Bloomberg: AstraZeneca Seroquel Studies ‘Buried,’ Papers Show (Update3)